Notice the NOT in the title. Instead of listing what you should watch, I'll list why you might want to skip these programs (although I have an idea that you will anyway).
Prison Break - Fox
All right, so Michael breaks his brother out of prison, there's an entire season devoted to the chase, and eventually his brother's name is cleared and all is well.
And then the dumbfucks at Fox decide to milk this cash cow's dick for all it's worth and have Michael be the one in prison and his brother breaking him out instead. They should have ended the entire TV series at last season.
See, most of these primetime dramas need to know when to quit, instead of doing something because they want to get rich. They need to take a page from most anime studios, that usually quit a series before it gets stale (except for DBZ and Naruto and possibly Inu Yasha and Yugioh, which means there may be some rich American CEO mentality in Japan).
Heroes - NBC
I'll give this series props for at least semi-wrapping up the series at the end. But damn did I get kinda bored with this. It had it's moments, but seriously, this is a show about superhuman powers. Instead of spending 90% of the show having people talk and shit, show some fucking superpowers. I expected this mass melee with a page straight out of the League of Superheros with all the heroes in the show fighting this epic battle and shit blowing up. For a show about superheroes, the ending was anticlimatic, and it seriously lacked special effects and awesome super battles.
This may be worth watching only if they redeem themselves in the second season.
Lost - ABC
I never got started with this show, and I really don't feel like it, because every time I try to sit down and watch this, I'm confused as all fuck. The show has a billion open plotlines, it's been dragging on forever, it's impossible to jump into the series at any point in the series besides the beginning, and there's no end in sight, and no answers to all the questions in sight. Like, for instance, what the fuck that shadow creature is. What's with the bunker with the timer and button? Why, when watching one episode, did I see what appeared to be a suburban household... on a deserted island?!
The way this show drags on with filler and crap reminds me of another show. What was it called again? Oh wait, that's right... Inuyasha. Dude, end the pain now, please!
A show I might watch (but will probably suck anyway):
Cavemen. A show based directly off the cavemen characters from the Geico commercials. And since those commercials suck, I have a feeling this will suck too. But I'll give it a shot anyway.