I generally avoid Doomsday stuff. He, like Bane, was only dreamed up as a means selling books with Superman temporarily dying. There's just nothing to him but killing and being used by others to do their killing. The single best scene ever featuring Doomsday was the tiny panel in Infinite Crisis where Kal-L Earth-2 Golden Age Old Superman catches his punch in mid-air, says, "not this time, monster," and literally punches his jaw off.
But apparently it has him trying to kill the four Supermen from the Reign of the Supermen storyline, which could be fun. Superboy just got over dying not long ago, so he's safe. Eradicator has been crap for years since he quit being Punisher Superman after Henshaw blew his ass to smithereenies, so the magic eight ball says he croaks. Steel probably won't make it, either, as he hasn't been dead in a while...the last time being at the hands of--take a wild guess--Doomsday. Natch.
And then there's Cyborg Superman...so that ought to be cool, since Doomsday has had a beef with Henshaw ever since he launched his ass into deep space while he was dead/unconscious from the beating The Real Effin' Superman gave him in Superman #75. And Henshaw's so bad-ass the only guy who otherwise had a shot at killing him was the Anti-monitor...and that includes Darkseid in the figuring.
It took every Kryptonian on New Krypton to kill Doomsday last time, so I don't see yet how they're going to up the ante.