I've been up for 2 nights straight. I do not recommended it. The body needs sleep.
You've been awake all this time? You dum-dum. You're an old woman now. Lack of sleep will only make you wrinkle faster.
And D, FTW? You've seriously been missing out. Even for a non-drinker, asocial reclusive non-partier like myself, staying up all night in my shell is a treat! Granted I was only able to do it once I was an adult, but aren't you suppose to pass for one or some junk? What the hell, man? I only recall one time where I was up over a complete day and that was several years back. Every other time I've managed to sneak in sleep somewhere.